周昌艷; 唐慶九; 白韻琴; 楊焱; 賈薇
上海市農(nóng)業(yè)科學(xué)院食用菌研究所; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所 上海201106 ; 上海201106 ; 上海201106 ; 上海201106 ; 上海201106

【中文摘要】 以靈芝子實(shí)體有效成分復(fù)配的靈芝康泰粉劑 ,對(duì)荷動(dòng)物S - 180實(shí)體瘤與EAC腹水瘤的雌雄小鼠進(jìn)行腫瘤抑制試驗(yàn)。口服 0 .5 g/kg·day和 1.5 g/kg·day靈芝康泰粉劑能明顯抑制動(dòng)物S - 180實(shí)體瘤的生長(zhǎng) ,延長(zhǎng)EAC腹水瘤動(dòng)物的平均生存時(shí)間 ,對(duì)S - 180的抑瘤率為 4 1.2 2 %～ 4 1.30 %和 4 5 .65 %～ 5 0 .0 0 %。急性毒性試驗(yàn)表明 ,靈芝康泰粉劑對(duì)雌雄小鼠的經(jīng)口LD50 均大于 10 g/kg ,微核試驗(yàn)和Ames試驗(yàn)均為陰性 ,未見(jiàn)致突變性。 30d喂養(yǎng)試驗(yàn)發(fā)現(xiàn) ,靈芝康泰粉劑對(duì)試驗(yàn)動(dòng)物的生長(zhǎng)發(fā)育無(wú)不良影響。

【英文摘要】 Lingzhikangtai powder, composed of effective components from fruitbodies of Ganoderma lucidum had significant anti tumour activity against Lewis lung cancer, S 180 tumour and EAC ascitic tumour of Kuming mice. The results showed that Lingzhikangtai powder could significantly suppress the growth of S-180 and prolong the average life span of EAC mice with an oral dosage of 0.5g and 1.5g/kg, and that its anti tumour ratio was 41.22% ～41.30% and 45.65～50.00% respectively. And the result of acute toxicity test showed that the oral LD 50 of Lingzhikangtai powder was above 10g/kg to both male and female mice, and its micronucleus test and Ames test were all negative without mutation inducing effect. While the result of 30d feeding test showed that Lingzhikangtai powder was safe without harmful effect on the growth of the animal tested.

【中文關(guān)鍵詞】 靈芝; 活性成分; 腫瘤抑制作用; 毒理學(xué); 安全性
【英文關(guān)鍵詞】 Ganoderma lucidum; Effective component; Tumour-suppressive function; Toxicology; Safety

【文獻(xiàn)出處】 食用菌學(xué)報(bào),Acta Edulis Fungi,編輯部郵箱,2001年04期 【DOI】CNKI:SUN:SYJB.0.2001-04-007