【作者】唐慶九; 季哲; 郝瑞霞; 劉艷芳; 楊焱; 張勁松

【Author】TANG Qingjiu; JI Zhe; HAO Ruixia; LIU Yanfang; YANG Yan; ZHANG Jinsong National Engineering Research Center of Edible Fungi; Key Laboratory of Applied Mycological Resources and Utilization; Ministry of Agriculture; People’s Republic of China; Key Laboratory of Agricultural Genetics and Breeding of Shanghai; Research Center of Natural Medicinal Resources; Institute of Edible Fungi; Shanghai Academy of Agricultural Sciences; Shanghai 201106; China

【作者機(jī)構(gòu)】國(guó)家食用菌工程技術(shù)研究中心; 農(nóng)業(yè)部應(yīng)用真菌資源與利用重點(diǎn)開(kāi)放實(shí)驗(yàn)室; 上海市農(nóng)業(yè)遺傳育種重點(diǎn)開(kāi)放實(shí)驗(yàn)室; 上海市農(nóng)業(yè)科學(xué)院天然藥用資源研究開(kāi)發(fā)中心; 上海市農(nóng)業(yè)科學(xué)院食用菌研究所

【摘要】 從靈芝(Ganoderma lucidum)子實(shí)體中分離純化得到中性三萜部分,經(jīng)HPLC檢測(cè)發(fā)現(xiàn)主要有8個(gè)峰,與靈芝三萜酸性部分的峰基本不重疊。靈芝中性三萜部分對(duì)多種腫瘤細(xì)胞的增殖有抑制作用,并觀察到可誘導(dǎo)腸癌SW620細(xì)胞凋亡。

【Abstract】 A neutral triterpene fraction (NTF) isolated from Ganoderma lucidum fruit bodies was shown by HPLC to consist of eight major components which differed from the constituents in an acidic triterpenoid fraction (ATF). The NTF inhibited the proliferation of several tumor cell lines and induced apoptotic bodies in SW620 tumor cells.

【關(guān)鍵詞】 靈芝; 靈芝三萜; 抗腫瘤; 細(xì)胞凋亡

【Key words】 Ganoderma lucidum; antitumor; neutral triterpene; apoptosis

【基金】上海市科委國(guó)際合作項(xiàng)目“靈芝誘導(dǎo)腸癌細(xì)胞凋亡的活性成分及作用機(jī)制的研究”(編號(hào):044307041)的部分研究?jī)?nèi)容
 

【文獻(xiàn)出處】 食用菌學(xué)報(bào),Acta Edulis Fungi,編輯部郵箱,2010年01期

【DOI】CNKI:SUN:SYJB.0.2010-01-014

【分類(lèi)號(hào)】R285